Cast
| Cillian Murphy | J. Robert Oppenheimer |
| Emily Blunt | Kitty Oppenheimer |
| Robert Downey Jr. | Lewis Strauss |
| Matt Damon | Leslie Groves Jr. |
| Rami Malek | David Hill |
| Florence Pugh | Jean Tatlock |
| Ben Safdie | Edward Teller |
| Michael Angarano | Robert Serber |
| Josh Hartnett | Ernest Lawrence |
| Kenneth Branagh | Niels Bohr |
| Casey Affleck | Boris Pash |
| Dane DeHaan | Kenneth Nichols |
| Dylan Arnold | Frank Oppenheimer |
| David Krumholtz | Isidor Rabi |
| Alden Ehrenreich | Senate Aide |
| Matthew Modine | Vannevar Bush |
| Josh Peck | Kenneth Bainbridge |
| Gary Oldman | Harry Truman |
| Jason Clarke | |
| Jack Quaid | |
| David Dastmalchian | |
| Olli Haaskivi | |
| James D'Arcy | |
| Guy Burnet | |
| Danny Deferrari | |
| Matthias Schweighöfer | |
| Harrison Gilbertson | |
| Emma Dumont | |
| Devon Bostick | |
| Alex Wolff | |
| Trond Fausa |
Crew
| Christopher Nolan | Director, Producer, Screenwriter |
| Emma Thomas | Producer |
| Charles Roven | Producer |
| Hoyte Van Hoytema | Cinematographer |
| Jennifer Lame | Film Editing |
| Ludwig Göransson | Original Music |